Phenotypic and Functional Properties of Tumor-Infiltrating Regulatory T Cells

Phenotypic and Functional Properties of Tumor-Infiltrating Regulatory T Cells

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Regulatory T (Treg) cells maintain immune homeostasis by suppressing excessive immune responses.Treg cells induce tolerance against self- and foreign antigens, thus preventing autoimmunity, allergy, graft rejection, and fetus rejection during pregnancy.However, Treg cells also infiltrate into iphone xr price calgary tumors and inhibit antitumor immune responses, thus inhibiting anticancer therapy.

Depleting whole Treg cell populations in the body to enhance anticancer treatments will produce deleterious autoimmune diseases.Therefore, understanding the precise nature of tumor-infiltrating Treg cells is essential for effectively targeting Treg cells in tumors.This review summarizes recent results relating to Treg cells in the tumor microenvironment, with particular emphasis on their accumulation, phenotypic, and nitrile gloves in a bucket functional properties, and targeting to enhance the efficacy of anticancer treatment.